Pathomorphology of cutaneous mastocytosis

Introduction . Mastocytosis as a result of mast cell infiltration the skin and other organs develops at any age. The relevance this work is determined by lack systematic data on pathomorphological features clinical forms types cutaneous mastocytosis, defined Consensus European-American Group WHO classification in 2016. variability dermatological manifestations children adults, difficulties interpreting laboratory tests create problem for verifying diagnosis further treatment. aim To determine main pathohistological mastocytosis. Material methods article includes from patients who were treated monitored Moscow Scientific Practical Center Dermatovenereology Cosmetology 2019–2022. Results literature own characteristic patterns that are important mastocytosis with lesions adults systematized. pathological substrate diffuse mastocytoma was massive infiltrate cells papillary reticular layers dermis. histological picture monomorphic type maculopapular (MPCM) characterized relatively lower density dermis compared to Also, children, affected significantly higher adults. In addition, PPCM, less infiltrated cells. This confirms opinion MPCM phenotypically similar Conclusions Further prospective follow-up may allow conclusions be drawn about prognostic value examination children.